DRUGS EFFECT
Targeted drugs used to treat cancer are usually designed to bind to a specific protein on/in the cells. A problem with this approach is that some normal cells may also have that protein, and they can be killed as well.
Now, nano-robots containing antibodies and short pieces of DNA have been used to refine the targeting process. In the experimental system, light can be produced, showing that the right cells have been found. The method should allow much more precise targeting of cancer cells...and less side effects.
...
Source: http://www.hss.edu/
Article: http://www.nature.com/nnano/
The molecular robots look nothing like the robot shown below...just a fun image. http://commons.wikimedia.org/
Targeted drugs used to treat cancer are usually designed to bind to a specific protein on/in the cells. A problem with this approach is that some normal cells may also have that protein, and they can be killed as well.
Now, nano-robots containing antibodies and short pieces of DNA have been used to refine the targeting process. In the experimental system, light can be produced, showing that the right cells have been found. The method should allow much more precise targeting of cancer cells...and less side effects.
...
Source: http://www.hss.edu/
Article: http://www.nature.com/nnano/
The molecular robots look nothing like the robot shown below...just a fun image. http://commons.wikimedia.org/
2 hours ago
Clinical trial watch:
In a national trial (Belle-2), a new drug, BKM120, is being tested against breast cancer. The new drug blocks an enzyme called PI3K and it is hoped that it will work against ER positive breast cancer that has progressed.
Source: http://clinicaltrials.gov/ct2/
In a national trial (Belle-2), a new drug, BKM120, is being tested against breast cancer. The new drug blocks an enzyme called PI3K and it is hoped that it will work against ER positive breast cancer that has progressed.
Source: http://clinicaltrials.gov/ct2/
5 hours ago
Not enough girls getting HPV vaccine!
The proportion of eligible girls getting the HPV vaccine only about one in two. This is despite the very good safety and effectiveness of the vaccine. Most of the girls that don't get the vaccine DO get other vaccines.
Why???
...
Many parents don't want to give their daughters the vaccine because they mistakenly believe that vaccination will make their daughters more sexually active. The reason that the vaccine is recommended for young girls is that it should be given BEFORE they become sexually active. Several studies have shown that being vaccinated does not encourage girls to engage in sex.
There is also the belief that the vaccine is not safe, even though NO deaths have been linked to the vaccine. There have been some side effects seen, but they are rare and temporary. The vaccine DOES prevent infection and can save lives!
Source: http://www.cdc.gov/media/
Article: http://www.cdc.gov/mmwr/
Image of HPV infected keratinocytes (skin cells) http://commons.wikimedia.org/
Not enough girls getting HPV vaccine!
The proportion of eligible girls getting the HPV vaccine only about one in two. This is despite the very good safety and effectiveness of the vaccine. Most of the girls that don't get the vaccine DO get other vaccines.
Why???
...
Many parents don't want to give their daughters the vaccine because they mistakenly believe that vaccination will make their daughters more sexually active. The reason that the vaccine is recommended for young girls is that it should be given BEFORE they become sexually active. Several studies have shown that being vaccinated does not encourage girls to engage in sex.
There is also the belief that the vaccine is not safe, even though NO deaths have been linked to the vaccine. There have been some side effects seen, but they are rare and temporary. The vaccine DOES prevent infection and can save lives!
Source: http://www.cdc.gov/media/
Article: http://www.cdc.gov/mmwr/
Image of HPV infected keratinocytes (skin cells) http://commons.wikimedia.org/
The proportion of eligible girls getting the HPV vaccine only about one in two. This is despite the very good safety and effectiveness of the vaccine. Most of the girls that don't get the vaccine DO get other vaccines.
Why???
...
Many parents don't want to give their daughters the vaccine because they mistakenly believe that vaccination will make their daughters more sexually active. The reason that the vaccine is recommended for young girls is that it should be given BEFORE they become sexually active. Several studies have shown that being vaccinated does not encourage girls to engage in sex.
There is also the belief that the vaccine is not safe, even though NO deaths have been linked to the vaccine. There have been some side effects seen, but they are rare and temporary. The vaccine DOES prevent infection and can save lives!
Source: http://www.cdc.gov/media/
Article: http://www.cdc.gov/mmwr/
Image of HPV infected keratinocytes (skin cells) http://commons.wikimedia.org/
19 hours ago
New target found for triple negative breast cancer.
Triple negative breast cancer (TNBC) lacks three important proteins found on other breast cancers. Because of this, these cancers are harder to treat, more likely to recur, and have lower survival.
A genomic search performed in Singapore has identified at least one new potential target. The protein, called UBASH3B, is found at high levels in 1 in 3 TNBC patients. Blocking the activity of the gene reduces cancer spread in mouse models of breast cancer.
...
Source: http://www.a-star.edu.sg/
Research Article: http://www.pnas.org/content/
The image shows the progression of breast cancer that originates in the ducts of the breast. http://commons.wikimedia.org/
New target found for triple negative breast cancer.
Triple negative breast cancer (TNBC) lacks three important proteins found on other breast cancers. Because of this, these cancers are harder to treat, more likely to recur, and have lower survival.
A genomic search performed in Singapore has identified at least one new potential target. The protein, called UBASH3B, is found at high levels in 1 in 3 TNBC patients. Blocking the activity of the gene reduces cancer spread in mouse models of breast cancer.
...
Source: http://www.a-star.edu.sg/
Research Article: http://www.pnas.org/content/
The image shows the progression of breast cancer that originates in the ducts of the breast. http://commons.wikimedia.org/
Triple negative breast cancer (TNBC) lacks three important proteins found on other breast cancers. Because of this, these cancers are harder to treat, more likely to recur, and have lower survival.
A genomic search performed in Singapore has identified at least one new potential target. The protein, called UBASH3B, is found at high levels in 1 in 3 TNBC patients. Blocking the activity of the gene reduces cancer spread in mouse models of breast cancer.
...
Source: http://www.a-star.edu.sg/
Research Article: http://www.pnas.org/content/
The image shows the progression of breast cancer that originates in the ducts of the breast. http://commons.wikimedia.org/
Yesterday at 8:04am
Do bigger animals get more cancer?
If cancer is something that happens more or less randomly when cells get damaged, it is reasonable to think that larger animals (which have more cells) would get cancer more than smaller animals. It turns out that this is not true. This is called 'Peto's paradox' after the biologist who first discovered it.
WHY don't big animals get more cancer? That is an area of research and debate. One possibility is that small animals, like mice, put more energy into avoiding being eaten and into reproducing quickly. Larger animals, like a whale, live longer and can put more of their energy into fighting off things like cancer.
...
Source: http://en.ird.fr/
Research links: http://www.ncbi.nlm.nih.gov/
http://www.biomedcentral.com/
Do bigger animals get more cancer?
If cancer is something that happens more or less randomly when cells get damaged, it is reasonable to think that larger animals (which have more cells) would get cancer more than smaller animals. It turns out that this is not true. This is called 'Peto's paradox' after the biologist who first discovered it.
WHY don't big animals get more cancer? That is an area of research and debate. One possibility is that small animals, like mice, put more energy into avoiding being eaten and into reproducing quickly. Larger animals, like a whale, live longer and can put more of their energy into fighting off things like cancer.
...
Source: http://en.ird.fr/
Research links: http://www.ncbi.nlm.nih.gov/
http://www.biomedcentral.com/
If cancer is something that happens more or less randomly when cells get damaged, it is reasonable to think that larger animals (which have more cells) would get cancer more than smaller animals. It turns out that this is not true. This is called 'Peto's paradox' after the biologist who first discovered it.
WHY don't big animals get more cancer? That is an area of research and debate. One possibility is that small animals, like mice, put more energy into avoiding being eaten and into reproducing quickly. Larger animals, like a whale, live longer and can put more of their energy into fighting off things like cancer.
...
Source: http://en.ird.fr/
Research links: http://www.ncbi.nlm.nih.gov/
http://www.biomedcentral.com/
July 26 at 2:20pm
Billions and billions of pieces of the cancer puzzle...
The NCI-60 an group of sixty different cancer cell lines from humans. (A cell line is made by growing cancer cells in the lab. If they can grow forever, they are considered a cell 'line'.) Researchers have used the cell lines to collect information on the differences between their genes. Over 6 BILLION pieces of information are organized and stored in the new collection (called a database). The database is the largest of its kind, available to the public, and very well defined. All scientists can use the information provided in the database to conduct new cancer research.
Data was collected on the ten most frequently mutated genes seen in the lines, helping researchers identify potential drug targets as and drug responses. Scientists hope the database will allow many researchers to use the cell lines in experiments and explore drug treatments.
...
Source http://www.aacr.org/home/
Research Article http://
Image of HeLa cells, the first cancer cells made into a cell line. HeLa cells have been growing since the early 1950s. The patient (Henrietta Lacks) from whom they were taken died in 1951. These cells have been stained to give them the colors. http://en.wikipedia.org/wiki/
Billions and billions of pieces of the cancer puzzle...
The NCI-60 an group of sixty different cancer cell lines from humans. (A cell line is made by growing cancer cells in the lab. If they can grow forever, they are considered a cell 'line'.) Researchers have used the cell lines to collect information on the differences between their genes. Over 6 BILLION pieces of information are organized and stored in the new collection (called a database). The database is the largest of its kind, available to the public, and very well defined. All scientists can use the information provided in the database to conduct new cancer research.
Data was collected on the ten most frequently mutated genes seen in the lines, helping researchers identify potential drug targets as and drug responses. Scientists hope the database will allow many researchers to use the cell lines in experiments and explore drug treatments.
...
Source http://www.aacr.org/home/
Research Article http://
Image of HeLa cells, the first cancer cells made into a cell line. HeLa cells have been growing since the early 1950s. The patient (Henrietta Lacks) from whom they were taken died in 1951. These cells have been stained to give them the colors. http://en.wikipedia.org/wiki/
The NCI-60 an group of sixty different cancer cell lines from humans. (A cell line is made by growing cancer cells in the lab. If they can grow forever, they are considered a cell 'line'.) Researchers have used the cell lines to collect information on the differences between their genes. Over 6 BILLION pieces of information are organized and stored in the new collection (called a database). The database is the largest of its kind, available to the public, and very well defined. All scientists can use the information provided in the database to conduct new cancer research.
Data was collected on the ten most frequently mutated genes seen in the lines, helping researchers identify potential drug targets as and drug responses. Scientists hope the database will allow many researchers to use the cell lines in experiments and explore drug treatments.
...
Source http://www.aacr.org/home/
Research Article http://
Image of HeLa cells, the first cancer cells made into a cell line. HeLa cells have been growing since the early 1950s. The patient (Henrietta Lacks) from whom they were taken died in 1951. These cells have been stained to give them the colors. http://en.wikipedia.org/wiki/
July 26 at 9:55am
You've heard about rehab...what about pre-hab?
While most care focuses on the physical and mental health of patients during cancer treatment, research suggests that the time BEFORE treatment is also critical for patients. The treatment of patients during this times is called cancer 'prehabilitation', and it focuses on the patient during the time between when they are diagnosed and the start of treatment. During this time it is important for patients to have mental and physical health assessments to gauge their baseline level quality of life before treatment. This will allow them to be better cared for during treatment. Besides assessments, prehabilitation focuses on exercise and psychological guidance to help the patient be better prepared for what they might encounter during their cancer treatment. Research suggests that patients who get prehabilitation have better outcomes during and after treatment. It has even been shown to reduce healthcare costs.
Source: http://www.eurekalert.org/
Research Article: http://journals.lww.com/ajpmr/
While most care focuses on the physical and mental health of patients during cancer treatment, research suggests that the time BEFORE treatment is also critical for patients. The treatment of patients during this times is called cancer 'prehabilitation', and it focuses on the patient during the time between when they are diagnosed and the start of treatment. During this time it is important for patients to have mental and physical health assessments to gauge their baseline level quality of life before treatment. This will allow them to be better cared for during treatment. Besides assessments, prehabilitation focuses on exercise and psychological guidance to help the patient be better prepared for what they might encounter during their cancer treatment. Research suggests that patients who get prehabilitation have better outcomes during and after treatment. It has even been shown to reduce healthcare costs.
Source: http://www.eurekalert.org/
Research Article: http://journals.lww.com/ajpmr/
July 24 at 3:10pm
Boys need to get vaccinated against HPV too!
The human papillomavirus (HPV) is the MOST COMMON sexually transmitted agent. Vaccination against HPV is more common among women because of the well known association with cervical cancer, but the virus also causes penile cancers in men and anal and head/neck cancers in both men and women. Men pass the infection to their sex partners, making vaccination key to controlling the spread of the virus.
Source: https://media.utoronto.ca/
...
Research article: http://sti.bmj.com/content/
Image: Young boy receiving vaccination (in this case it is not against HPV...but he needs that too!) http://commons.wikimedia.org/
Boys need to get vaccinated against HPV too!
The human papillomavirus (HPV) is the MOST COMMON sexually transmitted agent. Vaccination against HPV is more common among women because of the well known association with cervical cancer, but the virus also causes penile cancers in men and anal and head/neck cancers in both men and women. Men pass the infection to their sex partners, making vaccination key to controlling the spread of the virus.
Source: https://media.utoronto.ca/
...
Research article: http://sti.bmj.com/content/
Image: Young boy receiving vaccination (in this case it is not against HPV...but he needs that too!) http://commons.wikimedia.org/
The human papillomavirus (HPV) is the MOST COMMON sexually transmitted agent. Vaccination against HPV is more common among women because of the well known association with cervical cancer, but the virus also causes penile cancers in men and anal and head/neck cancers in both men and women. Men pass the infection to their sex partners, making vaccination key to controlling the spread of the virus.
Source: https://media.utoronto.ca/
...
Research article: http://sti.bmj.com/content/
Image: Young boy receiving vaccination (in this case it is not against HPV...but he needs that too!) http://commons.wikimedia.org/
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